Novel pH-Responsive Triply Hydrophilic Block Copolymer with Reversible Micellization Property

摘要

Stimuli-responsive water-soluble and amphiphilic polymers have attracted much attention because their micelles can be produced or destroyed by changing the temperatute, pH, ionic strength, and solvent polarity. In this work, a triply hydrophilic block copolymer of poly (ethylene glycol) and poly(methacrylic acid-co-dimethylamine ethyl methacrylate) [PEO-P(MAA-co-DMAEMA)] was synthesized and characterized. The copolymer system is believed to have the potential for drug delivery applications due to the biocompatibility of MAA and DMAEMA.