Predicting Secondary Structure of All-Helical Proteins Using Hidden Markov Support Vector Machines

摘要

Our goal is to develop a state-of-the-art secondary structure predictor with an intuitive and biophysically-motivated energy model through the use of Hidden Markov Support Vector Machines (HM-SVMs), a recent innovation in the field of machine learning. We focus on the prediction of alpha helices and show that by using HM-SVMs, a simple 7-state HMM with 302 parameters can achieve a Q_α value of 77.6% and a SOV_α value of 73.4%. As detailed in an accompanying technical report, these performance numbers are among the best for techniques that do not rely on external databases (such as multiple sequence alignments).