THE EFFECT OF SURFACTANTS DURING SOLVENT EXTRACTION OF ERYTHROMYCIN-A FROM BUFFER AND FILTERED FERMENTATION BROTH

摘要

Solvent extraction of the antibiotic erythromycin-A from buffer and filtered fermentation broth into 1-decanol was investigated. The presence of the soluble surface active compounds (SAC) in the filtered broth led to a 45% reduction in mass transfer rates. The addition of Softanol 120 and Softanol 30 reduced extraction rates from the buffer, but had no effect on the broth extraction. Interfacial turbulence enhanced mass transfer by up to 55% for extraction from both buffer and filtered broth when SDS and LDS where present.