EFFECTS OF MECHANICAL STRAIN ON PROLIFERATION OF LUNG ADENOCARCINOMA CELL IN VITRO

摘要

Using FX-4000 strain unit, the proliferation in human lung adenocarcinoma AS49 cells that underwent mechanical strain for different waveform and frequency were studied. Image-pro system revealed that cellular proliferation rate (PR) reduced significantly after cells were subjected to squarewave and 0～15% elongation at 0.3Hz, 0.5Hz, 0.7Hz and 1.0Hz for 2h. The PR had no distinct difference for sinewave and lower frequency compared with control. It is concluded that squarewave and higher frequency play an important role in inhibiting proliferation for A549 cells.