Highly Stable conjugated polymer dots as multifunctional agents for photoacoustic imaging-guided photothermal therapy

摘要

The development of multifunctional organic nanomaterials is extremely essential fortheir in vivo cancer theranostic applications. In this study, we report a new BDT-IID basedconjugated polymer dots (Pdots) platform that can serve as multifunctional nanoprobes forphotoacoustic (PA) imaging-guided photothermal therapy (PTT). The novel BDT-IID Pdots arereadily fabricated though nanoreprecipitation and can absorb strongly in the near-infrared region(NIR, 650-700 nm). Furthermore, BDT-IID Pdots possess the stable nanostructure andextremely low biotoxicity. In particular, its photothermal conversion efficiency can be up to 45%.More importantly, our in vivo results exhibit that the BDT-IID Pdots are able to offerconcurrently enhanced PA imaging signals and sufficient photothermal effect. Consequently, theBDT-IID Pdots can be exploited as a unique theranostic nanoplatform for PA imaging-guidedPTT of tumors, holding great promise for their clinical translational development.