Carbon dioxide fixation by reversible pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910

摘要

Due to the abundance of CO_2 in nature and C-C bond forming properties, CO_2 fixing enzymes are of high interest. We found pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910 converting pyrrole-2-carboxylate to stoichiometric amounts of pyrrole and CO_2: We found the enzyme also catalyze the reverse carboxylation of pyrrole, which was studied and optimized in this work in order to describe this novel carbon dioxide fixation and to synthesize valuable pyrrole-2-carboxylate.