In-situ Permeability of Paclitaxel across Rat Gastrointestine from Oral Microemulsions

机译：紫杉醇口服微乳在大鼠胃肠道中的原位通透性

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The objective was to determine the rat gastrointestinal(GI) permeability (Peff) of paclitaxel (PAC) frommicroemulsions as compared to the clinical formulationTaxol?. The microemulsions LBM and CM because oftheir surfactant and digestible oil composition enhancedthe permeation of PAC across rat small intestine 8-fold ascompared to Taxol?.

机译：目的是从微乳状液中确定紫杉醇（PAC）在大鼠胃肠道（GI）的通透性（Peff），与临床配方Taxol？相比。微乳剂LBM和CM由于其表面活性剂和可消化的油成分而提高了PAC在大鼠小肠中的渗透性，是紫杉醇的8倍。

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来源
《Controlled Release Society annual meeting》|2004年|1-2|共2页
会议地点 Honolulu, HI(US)
作者
Adwoa O. Nornoo; Lisa Szwarcberg;
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Albany College of Pharmacy Albany NY 12208nornooa@acp.edu;

Albany College of Pharmacy Albany NY 12208;

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机译：口服药物后小肠的节段依赖性通透性：原位大鼠灌注的单次通过与Doluisio方法
3. Oral delivery of paclitaxel by polymeric micelles: A comparison of different block length on uptake, permeability and oral bioavailability [J] . Sze Lai Pan, Li Ho Yin, Lai Ka Lun Alan, Colloids and Surfaces, B. Biointerfaces . 2019,第期

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4. In-situ Permeability of Paclitaxel across Rat Gastrointestine from Oral Microemulsions [C] . Controlled Release Society annual meeting . 2004

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In-situ Permeability of Paclitaxel across Rat Gastrointestine from Oral Microemulsions

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