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CHEMOTHERAPEUTIC MICROEMULSION COMPOSITIONS OF PACLITAXEL WITH IMPROVED ORAL BIOAVAILABILITY.
CHEMOTHERAPEUTIC MICROEMULSION COMPOSITIONS OF PACLITAXEL WITH IMPROVED ORAL BIOAVAILABILITY.
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机译:口服生物可利用性增强的帕西他赛的化学治疗微乳成分。
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摘要
Pharmaceutical compositions suitable for oral administration comprising paclitaxel, a solvent, a surfactant, a substituted cellulosic polymer, and optionally but preferably a P-glycoprotein inhibitor. The composition may further comprise a diglyceride or mixture of diglyceride and monoglyceride. The composition generates a supersaturated paclitaxel microemulsion upon contact with water resulting in improved oral bioavailability of paclitaxel.
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