Simulation Methods in Uncovering New Regulatory Mechanisms in Signaling Pathways

摘要

The paper deals with in silico investigation of possible regulatory mechanisms involved in control of signaling pathways. As an example, the In-terferon-b activated pathway has been chosen. Though many processes involved in this pathway are known, there are still some that evade explanation. One of them is the nuclear accumulation of the IRF1 protein. Here, three hypotheses are stated and tested numerically, showing that the most likely mechanism involved in this process is an inhibition of IRF1 activation by an yet unrecognized factor.