Efficacy of Modified Hemosorbents Used for Treatment of Patients with Multi-Organ Insufficiency

摘要

The treatment of patients with multiple organ failure is one of the most complex problems of modern medicine. The possibility to directly control physi-cochemical characteristics of medical sorbents using different technologies and chemical modification, in particular surface oxidation, is one of the approaches used to improve efficacy of hemosorption. The developed technique of oxidative sorbent modification by treatment with a solution of neutral anolite was used to modify the polymer pyrolyzed active carbon SKN-2 K. The modified hemosorb-ent was used to treat 31 patients with postoperative complications which led to multi-organ deficiency. The positive clinical outcomes included decrease of signs of intoxication syndrome, health improvement, and improvement in biochemical parameters after just one session of hemosorption. The reduction in the level of endogenous intoxication markers was statistically significant after the second session. It was established that the developed hemosorption technique allows the increase in the efficacy of biotransformation and elimination of toxic metabolic products, and stimulates cellular and humoral immune response. The hemosorption performed through a modified sorbent showed a favourable effect on the main parameters of the homeostasis system. The neutral anolite possesses anticoagulant and anti-aggregation properties. This allows for a reduction in heparin dosage during the procedure with the modified sorbent, therefore minimizing homeostasis system complications during the course of detoxification therapy. The total duration of the treatment was reduced by 41% and the hospitalisation period was 4.8 times shorter in comparison with the control group.