Molecular analysis of kanamycin ressitance of mycobacterium tuberculosis

摘要

Tuberculosis has reemerged as a significant public health problem. Furthermore, multiple-drug resistant (MDR) M. tuberculosis strains have become an additional handicap in the control of tuberculosis. Recently, to rapid diagnosis of MdR M. tuberculosis, considerable work has been done on the characterization of genes involved in drug resistance in mycobacteria. Kanamycin (KM) is an aminoglycoside antibiotic that was discovered by Umezawa et al. in 1957, and has been used as a second-line antibiotic for the treatment of tuberculosis. Although its usefulness had declined because of its toxicity, it has been revived because of MDR M.tuberculosis. Therefore, we have examined a molecular mechanism of kanamycin resistance of M.tuberculosis.