LUMINESCENCE STUDIES OF BLOOD PHAGOCYTE OXYGENATION ACTIVITIES IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME

摘要

The antiphospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis, recurrent pregnancy loss, increased cardiovascular risk, thrombocytopenia and the presence of circulating antiphosholipid antibodies (aPL). Many aPL are directed against neoepitopes of oxidized phospholipids suggesting that (1) oxidative events may be important in the pathophysiology of the antiphospholipid syndrome and (2) that oxidized phospholipids, present in oxidized LDL (oxLDL) as promoters of atherogenesis may give rise to common epitopes and common autoantibodies. In this study we investigated the systemic oxidative/antioxidative balance in patients with primary antiphospholipid syndrome (PAPS), patients with systemic lupus erythematosus without secondary APS (SLE), and patients with SLE plus secondary antiphospholipid syndrome (SAPS). The parameters of oxidative stress were related to circulating levels of oxLDL and antibodies to oxidized LDL (anti-oxLDL).