OligoChip To Identify HLA-B*5101: Association Study In Male Patients with Behcet's Disease

摘要

To investigate the association of HLA-B*5101 and male Behcet's disease (BD). HLA-B51 antigens and HLA-B51 allele genotyping in 27 BD patients and 53 healthy controls were performed by complement-dependent microlymphocyte toxicity assay, OligoChip and PCR-sequence specific primer (SSP) method. HLA-B51 was found in 63%( 17/27) of BD patients and in 15.1% (8/53) of controls<0.0001，OR=11.7, 95%CI 3.9-35.4）.All of HLA-B51 antigen positive patients and controls were HLA-B*5101.The genotype frequency of HLA-B*5101 allele was significantly increased in males (42.3% in females versus 80% in males), with an OR of 5.6 (95%CI 1.1-29.3, P<0.05). Similar to other groups, HLA-B*5101 might be a susceptible gene for BD, and it was strongly correlated with male BD.