Clinicopathological Features of Endometrial Carcino-ma Associated with Lynch Syndrome in China

摘要

Background and objective:To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China.rn Conclusion:Some clinicopathological features of Lynch syndrome-associated endometrial carcinoma, such as early onset and multiple primary carcinomas, are similar in the Chinese and American/European populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. An increased number of grade 1 endometrioid tumors and a better prognosis imply better biobehavior in Chinese Lynch syndrome-associated endometrial carcinoma. Obesity may be a co-contributing factor for development of Lynch syndrome associated endometrial cancer in China.