POLYMERIC COMPOSITIONS OF MONOMETHYL FUMARATE IN TREATING RELAPSING REMITTING MULTIPLE SCLEROSIS AND PSORIASIS

摘要

The present invention comprises compounds of formula (I): where R1 may be PEG or other polymeric moieties. For example, R1 may be repeating PEG units - (CHs-CH2-O)n-, wherein n = 1 - 455. R1 may also be other polymeric moieties of varying sizes and structures, for example, R1 may be poly(glycolide), poly(lactic acid), poly(lactide), poly(caprolactone), poly(lactide-co-caprolactone), poly(lactideco-glycolide), or poly(lactic acid)-butanol. One or more embodiments of the invention may also relate to injectable pharmaceutical compositions comprising polymer conjugated monomethyl fumarate, and methods for treating relapsing-remitting multiple sclerosis and psoriasis.