THROMBOMODULIN FUNCTIONAL DOMAINS FOR USE IN PROMOTING OSTEOBLAST FUNCTIONS AND BONE HEALING

摘要

Thrombomodulin functional domains for use in promoting osteoblast functions and bone healing. Methods for stimulating bone regeneration, bone augmentation, treating a bone loss, a bone disorder and/or treating a bone-related disorder are disclosed. The method comprises administering, to a subject in need thereof a therapeutically effective amount of (I); a biologically, active recombinant polypeptide comprising, an amino acid sequence that is at least 80% identical to domains 2 and 3 of human thrombomodulin (TMD23); (II): an isolated polypeptide comprising recombinant TMD23 (rTMD23) or a biologically active recombinant variant thereof; or recombinant TMD23 (rTMD23) or a biologically active recombinant variant thereof, wherein the polypeptide is free of or lacking amino acid residues from domains 4 and 5 of the human thrombomodulin, and further wherein the biologically active variant thereof comprises an amino acid sequence that is at least 80% identical to the TMD23.