NEAR-INFRARED FLUORESCENT PROBES FOR MOLECULAR IMAGING OF BONE REPAIR

摘要

A probe for monitoring new bone formation and osseointegration containing an integrin α5β1 ligand conjugated to a near-infrared fluorescent dye in which the integrin α5β1 ligand is a cyclic peptide lacking an RGD sequence. Also disclosed is a bone repair and osteogenesis-monitoring probe formed of a bisphosphonate conjugated to a gold nanoparticle, the probe having a size of 1 nm to 10 nm. Further disclosed are two methods for monitoring bone formation, each of which is carried out by administering the above probes and obtaining a near-infrared fluorescence image.