Cell targeted molecules containing deimmunized Shiga toxin A subunit effector and CD8 + T cell epitope

摘要

The present invention provides a cell targeting molecule capable of delivering a CD8+ T cell epitope cargo to the MHC class I presentation pathway of target cells. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T cell epitope from the extracellular space to the MHC class I pathway of target cells, which target cells are malignant and/or non-immunogenic. It can be a cell. The target cells can then present the delivered CD8+ T cell epitopes complexed with MHC I molecules on the cell surface. The cell-targeting molecules of the present invention have applications including targeted labeling and/or killing of specific cell types within a mixture of cell types, including within chordates, and stimulation of a beneficial immune response. The cell targeting molecules of the present invention have application in the treatment of various diseases, disorders and conditions including, for example, cancer, tumors, proliferative disorders, immune disorders, and microbial infections.