Cell targeting molecules containing Shiga toxin A subunit effector and CD8 + T cell epitope

摘要

The present invention provides cell targeting molecules that can deliver CD8 + T cell epitope cargo into the MHC class I presentation pathway of cells. The cell targeting molecules of the present invention can be used to deliver virtually any CD8 + T cell epitope from the extracellular space to the MHC class I pathway of the target cell, which can be malignant and / or non-immune. It can be a cell. The target cell can then present on the cell surface the delivered CD8 + T cell epitope complexed with the MHC I molecule. The cell targeting molecules of the present invention have uses that include targeted labeling and / or killing of specific cell types within a mixture of cell types, including in chordates, and stimulating beneficial immune responses. The cell targeting molecules of the present invention have application in the treatment of various diseases, disorders, and conditions including, for example, cancer, tumors, proliferative disorders, immune disorders, and microbial infections.