NOVEL REPLICATION DEFICIENT INFLUENZA A VIRUS INDUCING HIGH LEVELS OF TYPE I INTERFERON

摘要

The present invention refers to a novel replication deficient influenza A virus which is inducing high levels of type I interferon (IFN) in cells infected by said virus, comprising an NS1 protein with a functional effector domain and a non-functional RNA binding domain with a deletion of at least 15 amino acids within the N-terminal 80 amino acids of the NS1 protein and its use for antiviral treatment.