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RADIOPHARMACEUTICAL KETONE AND DUAL TRACER IMAGING IN ALZHEIMER'S DISEASE, COGNITIVE IMPAIRMENT, AND OTHER CONDITIONS OF ALTERED CEREBRAL METABOLISM
RADIOPHARMACEUTICAL KETONE AND DUAL TRACER IMAGING IN ALZHEIMER'S DISEASE, COGNITIVE IMPAIRMENT, AND OTHER CONDITIONS OF ALTERED CEREBRAL METABOLISM
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机译:放射性药物酮和双示踪剂成像在阿尔茨海默病、认知障碍和其他脑代谢改变情况中的应用
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摘要
In certain aspects, the present disclosure relates to novel radiopharmaceutical ketone molecules, including acetoacetate (AcAc) and/or beta-hydroxybutyrate (BHB), and methods of using one or more radiopharmaceutical ketone molecules or radiopharmaceutical compositions as imaging agents or tracers in positron emission tomography (PET) or combination PET and magnetic resonance imaging (MRI), e.g., as ketone-PET tracers. The methods may be used in diagnostic imaging methodologies in Alzheimer's disease, cognitive impairment, and other conditions of altered cerebral metabolism.
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