首页> 外国专利> PHARMACEUTICAL COMPOSITION COMPRISING GLUCAGON/GLP-1/GIP TRIPLE AGONIST OR LONG-ACTING CONJUGATE THEREOF FOR PREVENTING OR TREATING LUPUS-RELATED DISEASES

PHARMACEUTICAL COMPOSITION COMPRISING GLUCAGON/GLP-1/GIP TRIPLE AGONIST OR LONG-ACTING CONJUGATE THEREOF FOR PREVENTING OR TREATING LUPUS-RELATED DISEASES

机译:包含胰高血糖素/GLP-1/GIP三重激动剂或其长效结合物的药物组合物,用于预防或治疗狼疮相关疾病

摘要

The present invention relates to a pharmaceutical composition for preventing or treating lupus-related diseases comprising a triple agonist, which activates a glucagon receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucose-dependent insulinotropic polypeptide (GIP) receptor, pharmaceutically acceptable salt thereof, solvate thereof, or long-acting conjugate thereof, the pharmaceutical composition reducing the size of inflammation-caused edema, improving skin lesions, and reducing the weight and size of the spleen in a lupus disease animal model.
机译:本发明涉及一种用于预防或治疗狼疮相关疾病的药物组合物,其包含激活胰高血糖素受体、胰高血糖素样肽-1(GLP-1)受体和葡萄糖依赖性促胰岛素多肽(GIP)受体的三重激动剂、其医药上可接受的盐、其溶剂化物或其长效结合物,在狼疮病动物模型中,该药物组合物减少了炎症引起的水肿的大小,改善了皮肤损伤,减轻了脾脏的重量和大小。

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