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METHOD FOR PRODUCTION OF FAST, INCLUSIVE AND HIGH-DOSE INACTIVE VACCINE TO BE USED AGAINST SARS-COV-2 VIRUS

机译:用于抗击SARS-COV-2病毒的快速、包容性和高剂量灭活疫苗的生产方法

摘要

The invention relates to the production method of inactive vaccine for SARS-COV-2 virus. Said method comprises the following process steps; isolating and culturing Sars-CoV-2 virus, concentrating the obtained virus solution, applying the process of aliquoting at different times on behalf of the characterization of possible genome variation and determination of the pool content, applying fractional 1st gamma irradiation such that equal irradiation is provided in the tubes of concentrated virus so as to provide inactivation by protecting the viral protein structure, applying lyophylisation after the application of said fractional 1st gamma irradiation, applying 2nd gamma irradiation such that equal irradiation is provided in the tubes of concentrated virus so as to provide the sterilization of the final product.
机译:本发明涉及SARS-COV-2病毒灭活疫苗的生产方法。所述方法包括以下工艺步骤;分离和培养Sars-CoV-2病毒,浓缩获得的病毒溶液,采用在不同时间进行等分的过程,以表征可能的基因组变异和确定池含量,应用部分1次伽马辐射,以便在浓缩病毒的管中提供相等的辐射,从而通过保护病毒蛋白质结构来提供失活,在应用所述部分1次伽马辐射后应用冻干,应用第二次伽马射线照射,使浓缩病毒管内的照射量相等,以便对最终产品进行灭菌。

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