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METHODS AND COMPOSITIONS FOR INHIBITING ADAM10 BIOLOGICAL ACTIVITIES
METHODS AND COMPOSITIONS FOR INHIBITING ADAM10 BIOLOGICAL ACTIVITIES
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机译:抑制ADAM10生物活性的方法和组合物
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摘要
Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirable cell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.
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机译:提供了修饰的分离的ADAM10调节肽和使用该方法的方法以调节ADAM10生物活性,抑制与受试者中的疾病,病症或病症相关的ADAM10生物学活性,包括但不限于降低炎症和抑制不良细胞增殖。 在一些实施方案中,修饰的分离的ADAM10调节肽基于SEQ ID NO:3或SEQ ID NO:4,并且在一些实施方案中包括在N-末端和/或所公开的肽的C末端处或附近的修改 以及在本文公开的ADAM10的氨基酸位置的一个或多个氨基酸位置的替代,插入和缺失。
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