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METHODS AND COMPOSITIONS FOR INHIBITING ADAM10 BIOLOGICAL ACTIVITIES
METHODS AND COMPOSITIONS FOR INHIBITING ADAM10 BIOLOGICAL ACTIVITIES
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机译:抑制ADAM10生物活性的方法和成分
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摘要
Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirablecell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.
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机译:提供了经修饰的分离的ADAM10调节肽及其使用方法来调节ADAM10的生物学活性,抑制与受试者的疾病,病症或病状相关的ADAM10的生物学活性,包括但不限于减少炎症和抑制不良的细胞增殖。在一些实施方案中,修饰的分离的ADAM10调节肽基于SEQ ID NO:3或SEQ ID NO:4,并且在一些实施方案中包括在所公开的肽的N末端和/或C末端或附近的修饰。以及本文公开的ADAM10前结构域肽的一个或多个氨基酸位置的取代,插入和缺失。
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