The present invention relates to a bio-sulfur manufacturing method for treating degenerative brain diseases (Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease). More specifically, sulfur powder is neutralized in sodium hydroxide (NaOH) aqueous solution and acetic acid (CH COOH) aqueous solution. Then, nitrogen (N2) is added to carbon dioxide, treated with supercritical synthetic carbon dioxide fluid generated at 80 ℃ temperature and 300 bar pressure for 30 minutes, and sprayed on a rapid cooling device at -20 ℃ to collect and freeze-dry. To provide a method for manufacturing bio sulfur that treats brain diseases (Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease). In addition, the biosulfur prepared by the method according to the present invention significantly reduces oxidative stress in HT22 cells, improves cell survival, and reduces nitrite, an inflammatory mediator induced by the addition of LPS in BV2 cells. .
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