首页> 外国专利> Bio-sulfur manufacturing method treat degenerative brain disease(Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease

Bio-sulfur manufacturing method treat degenerative brain disease(Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease

机译:生物硫制造方法治疗退行性脑疾病(阿尔茨海默病,帕金森病,Lou Gehrig的疾病

摘要

The present invention relates to a bio-sulfur manufacturing method for treating degenerative brain diseases (Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease). More specifically, sulfur powder is neutralized in sodium hydroxide (NaOH) aqueous solution and acetic acid (CH COOH) aqueous solution. Then, nitrogen (N2) is added to carbon dioxide, treated with supercritical synthetic carbon dioxide fluid generated at 80 ℃ temperature and 300 bar pressure for 30 minutes, and sprayed on a rapid cooling device at -20 ℃ to collect and freeze-dry. To provide a method for manufacturing bio sulfur that treats brain diseases (Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease). In addition, the biosulfur prepared by the method according to the present invention significantly reduces oxidative stress in HT22 cells, improves cell survival, and reduces nitrite, an inflammatory mediator induced by the addition of LPS in BV2 cells. .
机译:本发明涉及一种治疗退行性脑病(阿尔茨海默病,帕金森病,Lou Gehrig病的疾病)的生物硫制造方法。 更具体地,硫粉末在氢氧化钠(NaOH)水溶液和乙酸(CH COOH)水溶液中中和。 然后,将氮气(N 2)加入二氧化碳中,用超临界合成二氧化碳流体处理,在80℃温度下产生30分钟,并在-20℃的快速冷却装置上喷洒,收集和冷冻干燥。 为了提供一种制造生物硫的方法,可治疗脑病(阿尔茨海默病,帕金森病,Lou Gehrig病)。 另外,通过根据本发明的方法制备的生物硫磺显着降低了HT22细胞中的氧化应激,改善了细胞存活率,并减少了通过在BV2细胞中添加LPS引起的炎症介质。 。

著录项

  • 公开/公告号KR102350961B1

    专利类型

  • 公开/公告日2022-01-14

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR1020210073946

  • 发明设计人 송현;

    申请日2021-06-08

  • 分类号A61K33/04;A61P21;A61P25/16;A61P25/28;C01B17/02;

  • 国家 KR

  • 入库时间 2022-08-24 23:27:37

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