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Module differences of glucose metabolic brain network among Alzheimer’s disease, Parkinson’s disease dementia, Lewy body dementia and health control*

机译:阿尔茨海默氏病,帕金森氏病痴呆症,路易体痴呆症和健康控制之间的葡萄糖代谢性大脑网络的模块差异*

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Dementia has become a serious disease in elderly population. Graph theory based brain network analysis method is considered as a popular and universal technique in the field of the neurosciences. It can help neuroscientists to investigate the neuropathology of dementia, especially to understand dementia subtypes. However, brain network analysis for various dementia subtypes at the same time is still limited. The aim at this study is to investigate the similarities and differences in brain network modular parameters of three dementia subtypes: Alzheimer's disease (AD), Parkinson's disease dementia (PDD), Lewy body dementia (DLB). Health control has also been compared. All subjects of health control(HC), AD, PDD and DLB groups were from Huashan Hospital. Using topological analysis algorithms, we found that HC brain was divided into 4 modules; AD brain was divided into 4 modules; PDD brain was divided into 6 modules; and DLB brain was divided into 10 modules, which demonstrated differences in these dementia subtypes. We also found that right thalamus area was scattered in all dementia subtypes. After using the seed point correlation analysis, it can be seen that the connections between right thalamus and subcortical, frontal gyrus were enhanced and the connections with the occipital gyrus was attenuated in dementia subtypes. As a result, findings in this paper are expected to be useful for neuroscientists to further understand the pathology of AD, PDD and DLB.
机译:老年痴呆症已成为一种严重的疾病。基于图论的脑网络分析方法被认为是神经科学领域中一种流行的通用技术。它可以帮助神经科学家研究痴呆症的神经病理学,尤其是了解痴呆症的亚型。然而,同时针对各种痴呆亚型的脑网络分析仍然有限。这项研究的目的是调查三种痴呆亚型的脑网络模块参数的异同:阿尔茨海默氏病(AD),帕金森氏病痴呆(PDD),路易体痴呆(DLB)。健康控制也已进行了比较。健康控制,AD,PDD和DLB组的所有受试者均来自华山医院。使用拓扑分析算法,我们发现HC脑被分为4个模块。 AD大脑分为4个模块; PDD的大脑分为6个模块; DLB脑分为10个模块,这些模块显示出这些痴呆亚型的差异。我们还发现右丘脑区域散布在所有痴呆亚型中。使用种子点相关分析后,可以发现痴呆亚型的右丘脑与皮层下,额回之间的联系得到增强,与枕回的联系被减弱。结果,本文的发现有望对神经科学家进一步了解AD,PDD和DLB的病理学有用。

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