首页>
外国专利>
METHOD FOR TREATING ALZHEIMER'S DISEASE BY TARGETING MAPT GENE
METHOD FOR TREATING ALZHEIMER'S DISEASE BY TARGETING MAPT GENE
展开▼
机译:通过靶向MAPT基因治疗阿尔茨海默病的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
A polynucleotide, comprising the following base sequences: (a) a base sequence encoding a fusion protein of a nuclease-deficient CRISPR effector protein and a transcription repressor, and (b) a base sequence encoding a guide RNA targeting a continuous region of 18 to 24 nucleotides in length in a region set forth in SEQ ID NO: 54, 55, 56, 57, 68, 153 or 97 in the expression regulatory region of human MAPT gene. are expected to be useful for treating or preventing tauopathy including Alzheimer's disease.
展开▼
机译:包含以下基础序列的多核苷酸:(a)编码核酸酶缺陷型CRISPR效应蛋白和转录抑制剂的融合蛋白的碱基序列,以及(B)编码靶向18的连续区域的引导RNA的碱基序列 在人MapT基因的表达调节区中SEQ ID NO:54,55,56,57,68,153或97中所述的区域中长度的核苷酸。 预计将有助于治疗或预防包括阿尔茨海默病的疏境病。
展开▼