PERIPHERAL BLOOD BIOMARKER FOR EVALUATING ANTI-TUMOR IMMUNE EFFECT OF RADIATION THERAPY

摘要

Provided is a peripheral blood biomarker for evaluating the antitumor immune effect of radiation therapy. Also provided is a method in which the composition of cell subpopulation in a sample obtained from a subject is used as an index for immune activation in the subject caused by a radiation therapy. By comparing, with a reference, the amount of CD4+ T cell subpopulation that correlates with dendritic cell stimulation in an antitumor immune response or the amount of dendritic cell subpopulation that correlates with the dendritic cell stimulation in an antitumor immune response, the presence or absence of, and/or the magnitude of, immune activation occurring in the subject as a result of a radiation therapy can be determined.