URATE OXIDASE-ALBUMIN CONJUGATE HAVING CERTAIN NUMBER OF CONJUGATED ALBUMINS, AND METHOD FOR PRODUCING SAME

摘要

The present application relates to a method for producing urate oxidase containing non-natural amino acids, and urate oxidase produced thereby. It was confirmed that the method for producing urate oxidase containing non-natural amino acids disclosed herein allows drug delivery systems to be efficiently connected to proteins, and thus can be effectively used to increase the half-life of proteins to which connecting drug delivery systems was difficult. In addition, the urate oxidase produced by the method is characterized in that a drug delivery system is selectively connected to a specific site such that the efficacy of the urate oxidase is maintained, the drug persistence increases, the risk of immune response decreases, and a uniform conjugate is generated so as to be easy to isolate. Therefore, the urate oxidase can be usefully applied to various biodrugs.