METHOD FOR PRODUCING URATE OXIDASE WITH NON-NATURAL AMINO ACID INCORPORATED SITE-SPECIFICALLY, ALBUMIN CONJUGATE MANUFACTURING PROCESS AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

The present invention relates to a method for preparing a uric acid oxidase containing a non-natural amino acid, and to a uric acid oxidase prepared thereby. In the present invention, it was confirmed that the method of preparing a uric acid oxidase containing a non-natural amino acid can be effectively used to improve the half-life of a protein, which is difficult to connect the drug delivery system, since the drug delivery system is efficiently linked to the protein. In addition, the uric acid oxidase produced by the above method is selectively bound to a specific position to maintain drug efficacy, increases drug persistence, reduces the risk of immune reactions, and is easy to separate due to the creation of a uniform complex. It can be usefully used for the like