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Composition for Inhibiting Angiogenesis Using an Extract of Orostachys japonicus A. Berger
Composition for Inhibiting Angiogenesis Using an Extract of Orostachys japonicus A. Berger
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机译:使用Orostachys japonicus a. berger抑制血管生成的组合物
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摘要
The present invention relates to a composition for inhibiting proliferation of vascular endothelial cells , containing an extract of cultivated Wasong ( Orostachys japonicus A. Berger ), and cell cycle proteins related to cell survival in HUVEC such as CDK-2 (cyclin dependent kinase-2), CDK -4 (cyclin dependent kinase-4), Cyclin D1, and Cyclin E1 expression to suppress the G0/G1 cell cycle, and to be involved in the vascular endothelial growth factor receptor-2 (VEGFR-2) signaling pathway in HUVEC By inhibiting protein phosphorylation, it exhibits an effect of inhibiting proliferation of vascular endothelial cells, which is effective in inhibiting HUVEC angiogenesis.
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机译:本发明涉及一种抑制血管内皮细胞增殖的组合物,其含有培养的Wasong(Orostachys japonicus A. Berger)的提取物和与Huvec(如CDK-2)的细胞存活相关的细胞周期蛋白(细胞周期依赖性激酶-2 ),CDK -4(细胞周期蛋白依赖性激酶-4),细胞周期蛋白D1和细胞周期蛋白E1表达抑制G0 / G1细胞周期,并参与血管内皮生长因子受体-2(VEGFR-2)信号通路 Huvec通过抑制蛋白质磷酸化,它表现出抑制血管内皮细胞增殖的效果,这有效抑制Huvec血管生成。
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