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Targeted protein silencing using chimeras between antibodies and ubiquitination enzymes
Targeted protein silencing using chimeras between antibodies and ubiquitination enzymes
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机译:使用抗体和普发酶之间使用嵌合体的靶向蛋白质沉默
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摘要
The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immunospecifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers.
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