Circulating tumor cell based biomarker composition for diagnosis and prognosis of metastatic prostate cancer

摘要

The present invention relates to a biomarker composition for the diagnosis and prognosis of prostate cancer, and AR (Androgen receptor, androgen receptor), AR-V7 (Androgen receptor variant) in circulating tumor cells (CTC) isolated from a patient. 7, androgen receptor variant 7), EpCAM (Epithelial cell adhesion molecule), KRT-19 (Cytokeratin 19, Cytokeratin 19), PSA (Prostate specific antigen, PSMA) and PSMA (Prostate specific membrane) antigen, prostate-specific membrane antigen), by confirming that the detection rate and expression level of the gene combination is correlated with the level of malignancy of prostate cancer provided as a marker.