CIRCULATING TUMOR CELL-BASED BIOMARKER COMPOSITION FOR DIAGNOSIS AND PROGNOSIS PREDICTION FOR METASTATIC PROSTATE CANCER

摘要

The present invention relates to a biomarker composition for diagnosis and prognosis prediction for prostate cancer, and provides, by identifying that the detection ratio and expression level of a gene combination in circulating tumor cells (CTCs) isolated from a patient, the gene combination consisting of an androgen receptor (AR), androgen receptor variant 7 (AR-V7), an epithelial cell adhesion molecule (EpCAM), cytokeratin 19 (KRT-19), prostate-specific antigen (PSA), and prostate-specific membrane antigen (PSMA), are associated with the level of malignancy in prostate cancer, the gene combination as a biomarker for the diagnosis of prostate cancer and a biomarker for the prognosis prediction of prostate cancer.