GENETICALLY MODIFIED MEGAKARYOCYTE, MODIFIED PLATELET, AND METHODS RESPECTIVELY FOR PRODUCING SAID GENETICALLY MODIFIED MEGAKARYOCYTE AND SAID MODIFIED PLATELET

摘要

Provided is a method for producing a genetically modified megakaryocyte, the method comprising a step for introducing a CRISPR-associated (Cas) family protein and guide RNA (gRNA) into a megakaryocyte to modify a gene of interest, wherein the Cas family protein and the gRNA to be introduced into the megakaryocyte at said step are formed as a complex beforehand. The method is useful as a technique for producing a genetically modified megakaryocyte and a modified platelet.