N - 4-oxo-2,3-dihydro-1,5-benzoxazepine-3-yl - 5,6-dihydro-4h-pyrrolo 1 2-B) pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating irritable bowel syndrome (IBS)

摘要

The present invention relates toCompound having general formula (I) or its pharmaceutically acceptable saltXYR1R2R7aR7bXRB1Rb2NPQA ringAnd B ringAs described herein.Pharmaceutical composition containing the compoundFor example, Parkinson's disease or Alzheimer's diseaseIrritable bowel disorder (IBD)Crohn's diseaseAcute respiratory distress syndromeThis compound for use as a receptor coupled protein-1 (rip1) kinase inhibitor is provided in a method of treating chronic obstructive pulmonary disease (COPD).Exemplary compounds are, for example, Ki in rip1 assay μ M μ M (4S, 6S) - 4-fluoro-6-phenyl-n - [(3S) - 5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl] - 5,6-dihydro-4h-pyrrolo [1] 2-2) pyrazole-2-carboxamide (example 11).