Background: Several psychological factors have been linked to the etiology of irritable bowel syndrome (IBS). The aim of the present study was to assess the burden of psychological factors (anxiety, depression, and working status) in the etiology of IBS in Northern Saudi Arabia. Methodology: Data regarding IBS were attained from 930 Saudi volunteers existing in the city of Hail, Northern Saudi Arabia. A purposeful questionnaire was developed and used to obtain the required data. Each questionnaire was completed by a medical student in the course of the interview. Results: IBS symptoms were recognized in 46% of the study population of whom 38% were males and 62% were females. The risk of anxiety as a risk for IBS was statistically significant. The relative risk and 95% confidence interval (95% CI) = RR (95% CI) = 1.4801 (1.2608 to 1.7376), P Conclusion: IBS and IBS related symptoms are prevalent in Northern Saudi Arabia. IBS symptoms are significantly associated with anxiety, depression and to a lesser extent may be linked to occupation and daily working hours.
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