Genetically engineered bacteria containing genetically engineered Propionibacterium acnes and genetically engineered bacteria of Propionibacterium

摘要

Problem to be solved: to provide a pharmaceutical composition containing genetically modified bacteria.A pharmaceutical composition dispensed for administration to mammals;The composition comprisesContains a genetically engineered Propionibacterium acnes species (P. acnes species), which includes a control factor that is operably coupled to a nucleic acid encoding a mammalian growth factor or a mammalian cytokineThe above speciesExpressing the growth factor or mammalian cytokinesP. acnes speciesIncludes the CRISPR arrayThe control factor and the nucleic acidIntegrated into the P. acnes species genomeIt is a pharmaceutical composition.No selection