A Contrast Agent Composition for Detecting Lesional Margin of Dementia Caused by Degenerative Brain Disease Comprising Quinoline Derivatives as Active Ingredients

摘要

The present invention relates to a contrast agent composition for diagnosing astrocytosis, detecting reactive astrocytes, and obtaining images for lesion margins. The present invention provides the precise location of the dense area of these cells in various diseases accompanied by excessive proliferation or activation of astrocytes and provides reliable information on the boundary between the lesion area and the surrounding normal area, In particular, it can be usefully used as a diagnostic image for image-guided surgery in surgical resection of brain tumors and the like. In addition, the present invention shows not only the existence of a simple disease at the time of the examination, but also the process of changes in the boundary and area of the lesion site with high temporal resolution, based on this, to detect the recurrence or metastasis of a tumor in the early future, and furthermore, It can also be usefully used to evaluate therapeutic responsiveness.