Dendrovo design of potent and selective interleukin mimics

摘要

The large potential of interleukin, a central immune cytokine, such as IL-2 and IL-4 for cancer therapy, induced a number of efforts to improve their therapeutic characteristics by mutation and / or chemical modification.IL-2 receptor βγ C heterodimer (IL-2R) βγ IL-4 receptor αγ C heterodimer (IL-4R) αγ C) or IL-13 receptor α Subunit α） Disclosed is a method for designing and designing a deinovo designed polypeptide to bind to and also use the polypeptide.[Orig] Figure 3e