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A Method to Specifically Stimulate Survival and Expansion of Genetically-Modified Immune Cells
A Method to Specifically Stimulate Survival and Expansion of Genetically-Modified Immune Cells
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机译:一种特异性刺激遗传修饰免疫细胞的存活和扩增的方法
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摘要
The present invention relates to a vector encoding a wildtype or truncated form of erythropoietin receptor (EpoR) to promote T cell survival and proliferation. Specifically, it exemplifies a bicistronic vector that expresses a truncated EpoR with an anti-CD19-41 BB-003ζ chimeric antigen receptor (CAR) that has a greater ex vivo expansion than CAR-T cells and demonstrates a significantly higher anti-leukemic activity in vivo. It also describes the method of producing cells expressing said vector and the use of these cells to kill CD19+ tumour cells.
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