A METHOD TO SPECIFICALLY STIMULATE SURVIVAL AND EXPANSION OF GENETICALLY-MODIFIED IMMUNE CELLS

摘要

The present invention relates to a vector encoding a wildtype or truncated form of erythropoietin receptor (EpoR) to promote T cell survival and proliferation. Specifically, it exemplifies a bicist ronic vector that expresses a truncated EpoR with an anti-CD19-41 ΒΒ-003ζ chimeric antigen receptor (CAR) that has a greater ex vivo expansion than CAR- T cells and demonstrates a significantly higher anti-leukemic activity in vivo. It also describes the method of producing cells expressing said vector and the use of these cells to kill CD19+ tumour cells.