CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

摘要

The present invention relates to linkers having groups of propiolyl, substituted acryloyl (acryloyl) or substituted propanoyl, and the use of such linkers to bind compounds, particularly cytotoxic agents, to cell binding molecules. .