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Method for High-Sensitivity and High-Specificity Detection of Biomolecules by Using Mass Spectrometry
Method for High-Sensitivity and High-Specificity Detection of Biomolecules by Using Mass Spectrometry
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机译:通过使用质谱法测定生物分子的高灵敏度和高特异性检测的方法
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摘要
The present invention relates to a method for high-sensitivity and high-specificity detection of biomolecules by using mass spectrometry and, more specifically, to a method for high-sensitivity and high-specificity detection of proteins such as miRNA or antigens by using time-of-flight secondary ion mass spectrometry (ToF-SIMS), matrix-assisted laser desorption/ionization (MALDI), or laser desorption/ionization (LDI) mass spectrometry. The method for high-sensitivity and high-specificity detection of biomolecules by using mass spectrometry, according to the present invention, enables high-sensitivity and high-specificity detection of biomolecules by using surface mass spectrometry, and the method is expected to be used for the diagnosis and prediction of diseases by quantifying, from a biosample, a target probe such as miRNA which is known as a disease marker.
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