The present invention relates to new protein complexes which are useful for the treatment of cancer. These fusion proteins comprise (i) an immunocytokine comprising an antibody or antigen-binding fragment thereof fused to a cleavable peptide linker, and a cytokine, preferably IL-15, or a functional fragment thereof; and (ii) a cofactor which is preferably IL-15Rα or an IL-15-binding fragment thereof. Methods of treatment using these protein complexes are also disclosed.
展开▼
