A solvent-free cross-coupling reaction and a manufacturing method using that reaction

摘要

Prepare an aromatic compound (1) having a leaving group; an aromatic amino compound (2-1), diboronic acid esters (2-2), aromatic boronic acids (2-3), aromatic having a hydroxyl group. Prepare a cross-coupling reactive compound (2) selected from group compounds (2-4) and aromatic compounds with thiol groups (2-5); and palladium catalysts, bases, and carbon-carbon di. A cross-coupling reaction method comprising cross-coupling compound (1) and compound (2) in the presence of compound (4) having a heavy bond or a carbon-carbon triple bond without a solvent.