SOLVENT-FREE CROSS-COUPLING REACTION, AND PRODUCTION METHOD USING SAID REACTION

摘要

A cross-coupling reaction method including: preparation of an aromatic compound (1) that has a leaving group; preparation of a compound (2) capable of a cross-coupling reaction, the compound (2) being selected from aromatic amino compounds (2-1), diboronic acid esters (2-2), aromatic boronic acids (2-3), aromatic compounds (2-4) that have hydroxyl groups, and aromatic compounds (2-5) that have thiol groups; and cross-coupling reaction of compound (1) and compound (2) without a solvent in the presence of a palladium catalyst, a base, and a compound (4) that has a carbon-carbon double bond or a carbon-carbon triple bond.