Monoclonal Antibody Specific to Human and Monkey CD38 Antigen, Manufacturing Method and Use thereof

摘要

The present invention provides an amino acid sequence in which the antigen complementarity determining regions CDR1, CDR2 and CDR3 of the light chain variable region of an antibody are represented by SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; Monoclonal antibody that specifically binds to human and monkey CD38 antigens, wherein the antigen complementarity determining regions CDR1, CDR2 and CDR3 of the heavy chain variable region of the antibody contain the amino acid sequences shown in SEQ ID NO: 8, SEQ ID NO: 9 and SEQ ID NO: 10, respectively or derivatives thereof. The antibody or derivative thereof may be prepared as a component of a pharmaceutical composition or in a suitable pharmaceutical formulation, alone or in combination with other therapeutic means such as chemotherapy, for the treatment of benign tumors expressing CD38 such as human myeloma, human lymphoma, etc. used