Binding proteins and chimeric antigen receptor T cells targeting gasp-1 granules and their use

摘要

A method for detecting a cell with granules expressing G protein coupled receptor associated sorting protein 1 (gasp-1) or its fragments.A method of detection comprises (a) contacting a cell with an effective amount of binding protein (where the binding protein includes antigen binding fragments that specifically bind to gasp-1); And (b) can include identifying cells having granules bound to binding proteins.The gasp-1 granule may be in the cytoplasm or on the cell surface.There is also provided a method for producing a T-cell, including a chimeric antigen receptor, an anti gasp-1 antibody or a double specific binding protein.Further, there is provided a method for treating gasp-1 mediated diseases or inactivating exosomes, microvesicles or oncosomes.